TRITERPENOID AND STEROL COMPOUNDS ISOLATED FROM ANODENDRON PANICULATUM (ROXB.) A. DC.
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Keywords

Anodendron paniculatum
ursolic acid
esculentic acid
cycloartenol
desmosterol
cytotoxicity

How to Cite

1.
Hanh HTN, Canh VD, Dieu Huong HT, Duc HV, Hoai NT. TRITERPENOID AND STEROL COMPOUNDS ISOLATED FROM ANODENDRON PANICULATUM (ROXB.) A. DC. hueuni-jns [Internet]. 2017Aug.21 [cited 2024Mar.29];126(1B):145-53. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/4447

Abstract

This phytochemical study on the aerial parts of Anodendron paniculatum led to the isolation of three triterpenes, namely ursolic acid (1), esculentic acid (2), cycloartenol (3), and one sterol: desmosterol (4). Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds against the growth of human cancer cell lines was evaluated using the sulforhodamine B bioassay. Compounds 1 exhibited a moderate cytotoxicity against the LU–1 and MKN–7 cell lines with IC50 values of 44.37 ± 5.40 and 30.89 ± 3.60 μg/mL, respectively. Meanwhile, compound 4 possessed moderate cytotoxic effects toward the LU–1, KB, Hep–G2, MKN–7 and SW–480 cell lines with IC50 values ranging from 28.11 ± 1.95 to 41.41 ± 2.31 μg/mL.

https://doi.org/10.26459/hueuni-jns.v126i1B.4447
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