Chemical constituents and cytotoxicity of Aspidistra letreae
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Keywords

NMR
bioactivity
anticancer
cytotoxicity
extraction
isolation
structure elucidation

How to Cite

1.
Ho DV, Hoang HNT, Vo KM, Le AT, Nguyen HT. Chemical constituents and cytotoxicity of Aspidistra letreae. hueuni-jns [Internet]. 2020Jun.22 [cited 2024Mar.29];129(1B):31-9. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/5656

Abstract

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract from the whole plants of Aspidistra letreae exhibits moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

https://doi.org/10.26459/hueuni-jns.v129i1B.5656
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