Study on the efficacy of an inactivated Vibrio alginolyticus vaccine in preventing hemorrhagic disease in red drum (Sciaenops ocellatus)
Vol. 135 No. 3B (2026), Original Article
Vol. 135 No. 3B (2026)

Study on the efficacy of an inactivated Vibrio alginolyticus vaccine in preventing hemorrhagic disease in red drum (Sciaenops ocellatus)

Original Article
https://doi.org/10.26459/hueunijard.v135i3B.8426
Published 2026-05-22
Nguyen Quang Nam
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
Nguyen Thi Hue Linh
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
Nguyen Duc Quynh Anh
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
Nguyen Ngoc Phuoc
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam

Keywords

inactivated vaccine
marine aquaculture
Sciaenops ocellatus
vaccine safety
vibriosis nuôi cá biển
Sciaenops ocellatus
vaccine an toàn
vaccine bất hoạt
Vibriosis

Abstract

This study evaluated the efficacy of an inactivated whole-cell vaccine of Vibrio alginolyticus in preventing hemorrhagic disease in red drum (Sciaenops ocellatus). The V. alginolyticus strain (VA15) was selected from 20 isolates obtained from hemorrhagic diseased cage-cultured fish in coastal areas of Hue City, Vietnam, and was subsequently used for both vaccine preparation and challenge testing in red drum. The vaccine was prepared by formalin inactivation and administered via feed to assess its safety and protective efficacy in experimental fish. The results showed that the vaccine had no adverse effects on growth performance, feed conversion ratio, behavior, or the histological structure of the intestine and liver. Vaccinated fish exhibited enhanced immune responses, with significantly higher antibody titers than those of the control group. Following bacterial challenge, the relative percent survival (RPS) reached 44.2% in the single-dose group and increased to 53.5% in the booster group at a concentration of 10⁶ CFU eq/mL. These findings indicate that the inactivated whole-cell V. alginolyticus vaccine has potential as a safe and effective strategy for preventing hemorrhagic disease in red drum aquaculture.

https://doi.org/10.26459/hueunijard.v135i3B.8426

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