SIMULTANEOUS DETERMINATION OF AMLODIPINE, HYDROCHLOROTHIAZIDE AND VALSARTAN IN PHARMACEUTICAL PRODUCTS BY SPECTROPHOMETRIC -CHEMOMETRIC METHOD USING FULL SPECTRA
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1.
Trang NTQ, Bình TT, Tứ NV. SIMULTANEOUS DETERMINATION OF AMLODIPINE, HYDROCHLOROTHIAZIDE AND VALSARTAN IN PHARMACEUTICAL PRODUCTS BY SPECTROPHOMETRIC -CHEMOMETRIC METHOD USING FULL SPECTRA. hueuni-jns [Internet]. 2017Dec.7 [cited 2024Oct.13];126(1D):125-37. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/4584

Abstract

A procedure for simultaneous determination of amlodipine (AML), hydrochlothiazide (HYD) and valsartan (VAL) in pharmaceutical products was established basing on spectrophotometric – chemometric method using full spectra combined with Simulan program. The procedure was proved with good repeatability (relative standard deviation (RSD) values fluctuated from 2,2% to 2,3% for AML, HYD and VAL n = 3) and good trueness (recovery variations were 90,2% - 94,6% for AML, 91,3% - 95,5% for HYD, and 102,1-104,5% for VAL, n = 3) in terms of AML, HYD and VAL analysis in phamarceuticalproduct Exforge HCT. The results obtained by the developed method were agreed with those by high performance liquid chromatography (HPLC).

https://doi.org/10.26459/hueuni-jns.v126i1C.4584
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