Abstract
A procedure for simultaneous determination of amlodipine (AML), hydrochlothiazide (HYD) and valsartan (VAL) in pharmaceutical products was established basing on spectrophotometric – chemometric method using full spectra combined with Simulan program. The procedure was proved with good repeatability (relative standard deviation (RSD) values fluctuated from 2,2% to 2,3% for AML, HYD and VAL n = 3) and good trueness (recovery variations were 90,2% - 94,6% for AML, 91,3% - 95,5% for HYD, and 102,1-104,5% for VAL, n = 3) in terms of AML, HYD and VAL analysis in phamarceuticalproduct Exforge HCT. The results obtained by the developed method were agreed with those by high performance liquid chromatography (HPLC).
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