Chemical constituents and cytotoxicity of Aspidistra letreae
Vol. 129 No. 1B (2020), Original Article
Vol. 129 No. 1B (2020)

Chemical constituents and cytotoxicity of Aspidistra letreae

Original Article
https://doi.org/10.26459/hueuni-jns.v129i1B.5656
Published 2020-06-22
Duc Viet Ho
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
https://orcid.org/0000-0002-7442-3925
Hanh Nhu Thi Hoang
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
Khue Minh Vo
University of Education, Hue University, 34 Le Loi St., Hue, Vietnam
Anh Tuan Le
Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VAST, Dien Bien Phu St., Quang Tri, Vietnam
Hoai Thi Nguyen
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
PDF

Keywords

NMR
bioactivity
anticancer
cytotoxicity
extraction
isolation
structure elucidation

How to Cite

1.
Ho DV, Hoang HNT, Vo KM, Le AT, Nguyen HT. Chemical constituents and cytotoxicity of Aspidistra letreae. hueuni-jns [Internet]. 2020Jun.22 [cited 2024Nov.25];129(1B):31-9. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/5656
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX
Crossref
Scopus
Google Scholar
Europe PMC

Abstract

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract from the whole plants of Aspidistra letreae exhibits moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

https://doi.org/10.26459/hueuni-jns.v129i1B.5656
PDF

References

  1. Ly NS, Tillich HJ. Aspidistra averyanovii and A. parviflora (Asparagaceae) - Two new species from Central Vietnam. Phytotaxa. 2016;282(1):053-060.
  2. Mori Y, Kawasaki T. A new diosgenin glycoside, aspidistrin, from Aspidistra elatior Blume. Chemical & Pharmaceutical Bulletin. 1973;21(1):224-227.
  3. Cui JM, Kang LP, Zhao Y, Zhao JY, Zhang J, Pang X, et al. Steroidal saponins from the rhizomes of Aspidistra typica. PLoS ONE. 2016;11(3):e0150595.
  4. Peng J, Zhao Y, Xu L, Kang LP, Cui JM, Yu HS, et al. Metabolite profiling of steroidal glycosides in the rhizome of Aspidistra sichuanensis using UPLC/Q-TOF MSE. International Journal of Mass Spectrometry. 2017;415:63-84.
  5. Koketsu M, Kim M, Yamamoto T. Antifungal activity against food-borne fungi of Aspidistra elatior Blume. J. Agric. Food Chem. 1996;44:301-303.
  6. Xu X, Zhang Z, Chen Y, Yuan M, Yuan S, Bao J. Antiviral and antitumor activities of the lectin extracted from Aspidistra elatior. Zeitschrift für Naturforschung C. 2015;70(1-2):7-13.
  7. Liang X, Kong L, He M. A new homoisoflavone compound as a potent antibacterial agent from Aspidistra typica Baill. Journal of Chinese Pharmaceutical Sciences. 2016;25(9):700-703.
  8. Zuo S, Liu Y, Yang Y, Guo Z, Liu C, Guo Z, He H, Tu X, Zou K. Aspidsaponins A–D, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their cytotoxicity. Phytochemistry Letters. 2018;25:126-131.
  9. Averyanov LV, Tillich HJ, Le TA, Pham VT, Tatiana VM, Vu TC. Aspidistra letreae (Asparagaceae). A new species from central Vietnam. Phytotaxa. 2017;308(1):137-140.
  10. Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, et al. Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines. JNCI Journal of the National Cancer Institute. 1991;83(11):757-766.
  11. Duddeck H, Kaiser M. 13C NMR spectroscopy of coumarin derivatives. Organic Magnetic Resonance. 1982;20(2):55-72.
  12. Matsuo M, Urano S. 13C NMR spectra of tocopherols and 2,2-dimethylchromanols. Tetrahedron. 1976;32 (2):229-231.
  13. Pongprayoon U, Baeckström P, Jacobsson U, Lindström M, Bohlin L. Antispasmodic activity of beta-damascenone and E-phytol isolated from Ipomoea pes-caprae. Planta Med. 1992;58(1):19-21.
  14. Terada K, Honda C, Suwa K, Takeyama S, Oku H, Kamisako W. Acetylenic compounds isolated from cultured cells of Asparagus officinalis. Chemical & Pharmaceutical Bulletin. 1995;43(4):564-566.
  15. Zhang HJ, Sydara K, Tan GT, Ma C, Southavong B, Soejarto DD, et al. Bioactive constituents from Asparagus cochinchinensis. Journal of Natural Products. 2004;67(2):194-200.
  16. Xiang L, Wang Y, Yi X, Zheng G, He X. Bioactive spirostanol saponins from the rhizome of Tupistra chinensis. Steroids. 2016;108:39-46.
  17. Hayes PY, Jahidin AH, Lehmann R, Penman K, Kitching W, De Voss JJ. Steroidal saponins from the roots of Asparagus racemosus. Phytochemistry. 2008;69(3):796-804.
  18. Agrawal PK. Determining ring-F configuration in spirostane-type steroidal sapogenins by 1H-NMR. Indian Journ Chemical. 2005;44B:1092-1094.
  19. Ho DV, Hoang HTN, Vo HQ, Nguyen HM, Ain R, Nguyen HT. A new triterpene ester and other chemical constituents from the aerial parts of Anodendron paniculatum and their cytotoxic activity. Journal of Asian Natural Products Research. 2018;20(2):188-194.
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Copyright (c) 2020 Array