Antioxidant activity of some natural essential oils in Vietnam: Comparison between QSAR simulation and experimental study


Key words
natural essential oil
antioxidant activity

How to Cite

My TTA, Hieu LT, Hai NTT, Phuong TNM, Loan HTP, Thuy BTP, Nhung NTA. Antioxidant activity of some natural essential oils in Vietnam: Comparison between QSAR simulation and experimental study . hueuni-jns [Internet]. 2020Jun.30 [cited 2024Jun.22];129(1D):33-41. Available from:


The antioxidant activity of essential oils from leaves of Piper betle L. (T) and Cleistocalyx operculatus L. (V) and aerial parts of Ageratum conyzoides L. (H), indigenously grown in Thua Thien Hue province, Vietnam, is investigated. The quantitative structure–activity relationship (QSAR) model comprising 4-hydroxy-chromene-2H-one and its 26 derivatives is used to predict the radical scavenging activity of T, V, and H. The radical scavenging activity of the oils is experimentally determined with DPPH (1,1-diphenyl-2-picrylhydrazyl) via IC50 values. The experimental IC50 values are in good agreement with those obtained from the QSAR model. The IC50 value of Piper betle L. is 3.71 mg/mL, comparable to that of the strong antioxidant ascorbic acid (3.03 mg /mL).


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