The Synthesis of hybrid compounds of 24-nor-lupane triterpene and amino acids via C-28 amide linkage


24-nor-3-oxo-20(29)-lupen-28-oic acid, L-leucine, amide, hybrid compounds

How to Cite

Nguyen HS, Nguyen HT, Tran VL, Le NTG, Le CH, Ngo TUT, Dang TTA. The Synthesis of hybrid compounds of 24-nor-lupane triterpene and amino acids via C-28 amide linkage. hueuni-jns [Internet]. 2023Jun.30 [cited 2024Feb.26];132(1B):43-7. Available from:


Betulinic acid derivatives exhibit different biological activity against diversified targets, such as anticarcinogenic activity in experimental animals, anti-HIV, antihyperglycemia, and anti-inflammatory in humans. In this work, we investigated the synthetic procedure of 24-nor-3-oxo-20(29)-lupen-28-oic acid (1) derivatives. Starting from compound 1 and L-leucine methyl ester, we proceeded with amidification, reduction, and hydrolysis under basic conditions. Finally, three hybrid compounds were successfully synthesised and elucidated with spectral means.


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