Asymmetric synthesis of Ru(II)-dialkyl-pheox catalysts from (S)-2-Amino-phenylehanol for cyclopropanation
PDF (Vietnamese)

Keywords

Ru(II)-dialkyl-pheox
tổng hợp bất đối xứng
oxazoline
Ru(II)-pheox Ru(II)-dialkyl-pheox
asymmetric synthesis
oxazoline derivatives
Ru(II)-pheox catalyst

How to Cite

1.
Lê TLC, Iwasa S. Asymmetric synthesis of Ru(II)-dialkyl-pheox catalysts from (S)-2-Amino-phenylehanol for cyclopropanation. hueuni-jns [Internet]. 2023Mar.31 [cited 2024Nov.24];132(1A):55-63. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7056

Abstract

The development of new pharmaceutical products containing pure enantiomers is a recent direction in the world’s pharmaceutical industry. Asymmetric catalysts play an essential role in the synthesis of pure enantiomers. The Ru(II)-pheox catalyst has been reported to be effective for the asymmetric reactions producing pure enantiomers. In this study, an asymmetric synthesis of Ru(II)-dialkyl-pheox derivatives is proposed. The process consists of the asymmetric synthesis of oxazoline derivatives from precursors and the complexation between ruthenium and oxazoline ligands. With this procedure, four Ru(II)-dialkyl-pheox derivatives were successfully synthesized with a high yield (>60%).

https://doi.org/10.26459/hueunijns.v132i1A.7056
PDF (Vietnamese)

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