Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase
Vol. 133 No. 1B (2024), Original Article
Vol. 133 No. 1B (2024)

Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase

Original Article
https://doi.org/10.26459/hueunijns.v133i1B.7459
Published 2024-06-27
Nguyen Thi Ai Nhung*
Department of Chemistry, University of Sciences, Hue University, Hue, Vietnam
Nguyen Thi Thanh Hai
Department of Chemistry, University of Sciences, Hue University, Hue, Vietnam
Thanh Q. Bui
Department of Chemistry, University of Sciences, Hue University, Hue, Vietnam
https://orcid.org/0000-0003-4076-4323
Nguyen Vinh Phu
Faculty of Basic Sciences, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
https://orcid.org/0000-0003-2389-3422
Phan Tu Quy
Department of Natural Sciences & Technology, Tay Nguyen University, Buon Ma Thuot, Vietnam
https://orcid.org/0000-0002-5986-5944
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Keywords

Piper betle L
Colletotrichum gloeosporioide
in silico
ethanol extract
fungicidal alternative

How to Cite

1.
Nguyen Thi Ai N, Nguyen Thi Thanh H, Bui QT, Nguyen VP, Phan TQ. Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase. hueuni-jns [Internet]. 2024Jun.27 [cited 2024Dec.22];133(1B):109-23. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7459
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Abstract

Piper betle methanol extract and its compositional characteristics had been evidenced for their effective inhibitability against rice-blast fungus. In this work, they were subjected for further computational efforts to complete their bio-chemo-pharmacological profile, and broaden their anti-fungal potentiality against Colletotrichum gloeosporioides cutinase presentative (PDB-3DEA). As the results, the most noticeable promising inhibitors particularly regard to 5 (DS -10.8 kcal.mol-1; ground-state energy -499.50 a.u.; dipole moment 2.61 Debye; no toxicity; content 49.90 %) and 6 (DS -10.9 kcal.mol-1; ground-state energy -652.15 a.u.; dipole moment 2.82 Debye; no toxicity; content 13.23 %), given by both their natural contents and predicted properties. The theoretical retrievals would reinforce the antifungal activities of P. betle and be conducive to further efforts to develop a green fungicidal alternative with broad-spectrum and cost-effective pesticidal advantages.

https://doi.org/10.26459/hueunijns.v133i1B.7459
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