Optimizing the extraction process of paracetamol and chlorpheniramine maleate mixed in herb products

Abstract

In this study, we optimised the extraction procedure for paracetamol and chlorpheniramine maleate by using the response surface method with the Box-Behnken model. The influencing factors are ethanol concentration, extraction time, and liquid-to-solid ratio. The optimal extraction conditions for paracetamol and chlorpheniramine maleate mixed in medicinal herbs are as follows: ethanol concentration 96%; extraction time 14.04 minutes; liquid/ solid ratio 51.41 mL/g. Under these optimal conditions, the extraction efficiency of paracetamol and chlorpheniramine maleate is 98.10 and 95.64%, respectively. The optimization results were experimentally verified, showing a close agreement with the predicted model.