Evaluating polyphenol components, lung cancer cell inhibition, and antioxidant activity of Polyscias spp.
Vol. 134 No. 1S-3 (2025), Special Issue: CBA 2025
Vol. 134 No. 1S-3 (2025)

Evaluating polyphenol components, lung cancer cell inhibition, and antioxidant activity of Polyscias spp.

Special Issue: CBA 2025
https://doi.org/10.26459/hueunijns.v134i1S-3.7993
Published 2025-12-26
Mi Huynh
Institute of Food and Biotechnology, Can Tho University, Vietnam
Cong Thang Le
Institute of Food and Biotechnology, Can Tho University, Vietnam
Tung Chi Chim
Institute of Food and Biotechnology, Can Tho University, Vietnam
Le Khai Tran
Institute of Food and Biotechnology, Can Tho University, Vietnam
Do Tan Khang*
Institute of Food and Biotechnology, Can Tho University, Vietnam
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Keywords

Polyscias spp.
polyphenol
flavonoid
antioxidant
A549 lung cancer cells
ethanol extract

How to Cite

1.
Huynh M, Le CT, Chim TC, Tran LK, Do TK. Evaluating polyphenol components, lung cancer cell inhibition, and antioxidant activity of Polyscias spp. hueuni-jns [Internet]. 2025Dec.26 [cited 2025Dec.27];134(1S-3):125-3. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7993
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Abstract

Polyscias spp. is a traditional medicinal species widely used in Vietnam, but its polyphenol composition and related bioactivities have not been thoroughly examined. This study aimed to investigate the phytochemical compounds, total phenolic and flavonoid contents, antioxidant activity, and cytotoxic effect on A549 lung cancer cells from ethanol extracts of the roots, stems, and leaves of Polyscias fruticosa and Polyscias serrata species. Phytochemical screening reveals the presence of alkaloids, carotenoids, coumarins, flavonoids, polyphenols, quinones, saponins, tannins, and terpenoids in both species. The leaf extract of P. serrata has the highest total phenolic and flavonoid contents (47.097 mg GAE/g and 759.17 mg QE/g, respectively). The HPLC analysis indicates that quercetin was identified in P. fruticosa root only, while rutin was detected in all samples. The antioxidant activity was evaluated via DPPH and FRAP assays, with IC₅₀ values ranging from 1064 to 7417 µg/mL. The P. serrata leaf extract exhibited the most potent cytotoxic effect against A549 cells (IC₅₀ = 156.42 ± 5.07 µg/mL).

https://doi.org/10.26459/hueunijns.v134i1S-3.7993
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