Green-Synthesized NiFe₂O₄-CQDs Composite for Sensitive Electrochemical Detection of Acetaminophen and Caffeine
Vol. 134 No. 1D (2025), Original Article
Vol. 134 No. 1D (2025)

Green-Synthesized NiFe₂O₄-CQDs Composite for Sensitive Electrochemical Detection of Acetaminophen and Caffeine

Original Article
https://doi.org/10.26459/hueunijns.v134i1D.8029
Published 2025-12-24
Vo Chau Ngoc Anh*
University of Medicine and Pharmacy, Hue University, 530000, Vietnam
Mai Nguyen Do
University of Sciences, Hue University, 530000, Vietnam
Quang Man Nguyen
University of Medicine and Pharmacy, Hue University, 530000, Vietnam
Thi Huyen Thoa Pham
Department of Natural Sciences & Technology, Tay Nguyen University, 630000, Vietnam
Ngoc Tuyen Tran
University of Sciences, Hue University, 530000, Vietnam
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Keywords

NiFe2O4-CQDs composite
electrochemical sensing
acetaminophen
caffeine
differential pulse- anodic stripping voltammetry

How to Cite

1.
Vo CNA, Do MN, Nguyen QM, Pham THT, Tran NT. Green-Synthesized NiFe₂O₄-CQDs Composite for Sensitive Electrochemical Detection of Acetaminophen and Caffeine. hueuni-jns [Internet]. 2025Dec.24 [cited 2026Feb.5];134(1D):33-47. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/8029
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Abstract

In this study, a NiFe2O4-CQDs composite was synthesized and utilized to modify a glassy carbon electrode (GCE) for the simultaneous electrochemical detection of acetaminophen (ACP) and caffeine (CFE). The composite material was characterized using various techniques, including FTIR and PL spectroscopy, confirming its suitability for electrochemical applications. The DP-ASV method was employed to determine the limit of detection (LOD) for ACP and CFE, which were found to be 0.35 μM and 0.34 μM, respectively. The electrochemical method exhibited a wide linear range from 0.5 μM to 11.9 μM for both analytes. Optimized experimental conditions, including accumulation potential, accumulation time, and pulse amplitude, contributed to high sensitivity, reproducibility, and accuracy in detecting these compounds. Recovery studies in pharmaceutical samples demonstrated reliable results, with recoveries ranging from 94.2% to 103.2%. These findings suggest that the NIF-CQDs-modified GCE is a promising candidate for rapid and accurate electrochemical analysis of ACP and CFE in real-world applications.

https://doi.org/10.26459/hueunijns.v134i1D.8029
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