Flavonoid compounds from Passiflora foetida L. collected in Thua Thien Hue
PDF (Vietnamese)

Keywords

flavonoid
trị bệnh tiểu đường
α-amylase
α-glucosidase enzyme
Passiflora foetida L. flavonoid
antidiabetic activity
α-amylase
α-glucosidase enzyme
Passiflora foetida L.

How to Cite

1.
Phan TDT, Trần PH, Tôn TH Đạt, Cường LCV. Flavonoid compounds from Passiflora foetida L. collected in Thua Thien Hue. hueuni-jns [Internet]. 2026Mar.17 [cited 2026May22];135(1A):41-50. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7838

Abstract

Five flavonoid compounds: vitexin, vitexin 2ʹʹ-O-β-D-glucopyranoside, 2ʺ-O-rhamnosylvitexin, luteolin, and quercetin (1–5) were isolated from the leaves and stems of Passiflora foetida L. growing in Thua Thien Hue Province. Their chemical structures were elucidated by using nuclear magnetic resonance spectra as well as by comparing with the reported spectroscopic data. All the isolated compounds exhibited inhibitory activity against α-amylase and α-glucosidase enzymes with IC50 values ​​ranging from 123.6–743.4 µg/mL and 166.3–423.4 µg/mL, respectively. The results show the potential application of P. foetida in developing products to support diabetes treatment.

https://doi.org/10.26459/hueunijns.v135i1A.7838
PDF (Vietnamese)

References

  1. Chi VV. Từ điển cây thuốc Việt Nam. Hà Nội: Nhà xuất bản Y học; 2012.
  2. Viện Dược liệu – Bộ Y tế. Danh lục cây thuốc Việt Nam. Hà Nội: Nhà xuất bản Khoa học và Kỹ thuật; 2016.
  3. Aussavashai S, Donruedee S, Phanchana S, Ian HF, Nalin W. Quantitative determination of vitexin in Passiflora foetida Linn. leaves using HPTLC. Asian Pacific Journal of Tropical Biomedicine. 2016;6(3):216-220.
  4. Tý PV, Bảo NC. Các hợp chất phân lập từ dịch chiết methanol cây Lạc tiên (Passiflora foetida L.). Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên. 2017;126(1A):133-139.
  5. Lời H, Hùng T. Khảo sát thành phần hóa học cây Lạc tiên (Passiflora foetida – Passifloraceae). Tạp chí Dược liệu. 2011;16(1):24-28.
  6. Song Y, Zhu M, Hao H, Deng J, Li M, Sun Y, et al. Structure characterization of a novel polysaccharide from Chinese wild fruits (Passiflora foetida) and its immune-enhancing activity. International Journal of Biological Macromolecules. 2019;136:324-331.
  7. Sasikala V, Saravanan S, Parimelazhagan T. Analgesic and anti–inflammatory activities of Passiflora foetida L. Asian Pacific Journal of Tropical Medicine. 2011;4(8):600-603.
  8. Asadujjaman M, Ahmed UM, Aslam H, Utpal KK. Medicinal potential of Passiflora foetida L. plant extracts: biological and pharmacological activities. Journal of Integrative Medicine. 2014;12(2):121-126.
  9. Ahmad N, Chillara R, Kushwaha P, Khedgikar V, Karvande A, Choudhary D, et al. Evaluation of anti-osteoporotic activity of butanolic fraction from Passiflora foetida in ovariectomy-induced bone loss in mice. Biomedicine & Pharmacotherapy. 2017;88:804-813.
  10. Song Y, Wei X-Q, Li M-Y, Duan X-W, Sun Y-M, Yang R-L, et al. Nutritional composition and antioxidant properties of the fruits of a Chinese wild Passiflora foetida. Molecules. 2018;23(2):459.
  11. Dat TTH, Oanh PTT, Cuong LCV, Anh LT, Minh LTH, Ha H, et al. Pharmacological properties, volatile organic compounds, and genome sequences of bacterial endophytes from the mangrove plant Rhizophora apiculata Blume. Antibiotics (Basel). 2021;10(12):1491.
  12. Markham KR, Webby RF, Vilain C. 7-O-methyl-(2R:3R)-dihydroquercetin 5-O-β-D-glucoside and other flavonoids from Podocarpus nivalis. Phytochemistry. 1984;23(9):2049-2052.
  13. Zhang PC, Xu SX. C-glucoside flavonoids from the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. J Asian Nat Prod Res. 2003;5(2):131-136.
  14. Lin L-C, Pai Y-F, Tsai T-H. Isolation of Luteolin and Luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and Their Pharmacokinetics in Rats. Journal of Agricultural and Food Chemistry. 2015;63(35):7700-6.
  15. Bảo NC, Tý PV, Các hợp chất phân lập từ dịch chiết methanol cây Lạc tiên (Passiflora foetidal). Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên. 2017;126(1A):133-139.
  16. Dũng NV, Nguyễn DT, Phạm TVA, Lê CVC. Các hợp chất flavonoid từ phần trên mặt đất loài ban lá dính (Hypericum sampsonii Hance). Tạp chí Dược học. 2018;3.
  17. Yao Y, Cheng X, Wang L, Wang S, Ren G. A determination of potential α-glucosidase inhibitors from Azuki Beans (Vigna angularis). Int J Mol Sci. 2011;12(10):6445-51.
  18. Saltos MBV, Puente BFN, Faraone I, Milella L, Tommasi ND, Braca A. Inhibitors of α-amylase and α-glucosidase from Andromachia igniaria Humb. & Bonpl. Phytochemistry Letters. 2015;14:45-50.
  19. Yang Y, Gu L, Xiao Y, Liu Q, Hu H, Wang Z, et al. Rapid identification of α-glucosidase inhibitors from Phlomis tuberosa by Sepbox chromatography and thin-layer chromatography bioautography. PLOS ONE. 2015;10(2):e0116922.
  20. Hendra R, Army MK, Frimayanti N, Teruna HY, Abdulah R, Nugraha AS. α-glucosidase and α-amylase inhibitory activity of flavonols from Stenochlaena palustris (Burm.f.) Bedd. Saudi Pharmaceutical Journal. 2024;32(2):101940.
  21. Tan C, Wang Q, Luo C, Chen S, Li Q, Li P. Yeast α-glucosidase inhibitory phenolic compounds isolated from Gynura medica leaf. Int J Mol Sci. 2013;14(2):2551-8.
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