Characterization of the pilosebaceous microbiota and biofilm-forming capacity of bacteria isolated from patients with severe acne vulgaris
Vol. 135 No. 1S-1 (2026), Special Issue: IFB 2025
Vol. 135 No. 1S-1 (2026)

Characterization of the pilosebaceous microbiota and biofilm-forming capacity of bacteria isolated from patients with severe acne vulgaris

Special Issue: IFB 2025
https://doi.org/10.26459/hueunijns.v135i1S-1.8060
Published 2026-06-10
Mau Xuong Tu
Institute of Food and Biotechnology, Can Tho University, Cantho, Vietnam
Yen Nhi Pham
Institute of Food and Biotechnology, Can Tho University, Cantho, Vietnam
Huu Hau Tran
Institute of Food and Biotechnology, Can Tho University, Cantho, Vietnam
Ngoc Thanh Nguyen
Institute of Food and Biotechnology, Can Tho University, Cantho, Vietnam
Hoang Dang Long Bui
Institute of Food and Biotechnology, Can Tho University, Cantho, Vietnam
Ngoc Dung Tran
Can Tho University of Medicine and Pharmacy, Cantho, Vietnam
Huynh Xuan Phong*
Institute of Food and Biotechnology, Can Tho University, Cantho, Vietnam
PDF (Vietnamese)

Keywords

Cutibacterium anes
màng sinh học
mụn trứng cá
vi khuẩn vùng mặt Acne vulgaris
biofilm
Cutibacterium acnes
facial skin microbiota

How to Cite

1.
Từ MX, Phạm YN, Trần HH, Nguyễn NT, Bùi H Đăng L, Trần ND, Huỳnh XP. Characterization of the pilosebaceous microbiota and biofilm-forming capacity of bacteria isolated from patients with severe acne vulgaris. hueuni-jns [Internet]. 2026Jun.10 [cited 2026Jun.13];135(1S-1):103-12. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/8060
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Abstract

Acne vulgaris is a chronic inflammatory dermatological condition influenced by multiple factors, including endocrine dysregulation, immune responses, genetic predisposition, and particularly the skin microbiota. Dysbiosis within the pilosebaceous unit may exacerbate disease severity, in which biofilm formation plays a crucial role by promoting bacterial persistence and reducing antibiotic efficacy. This study aimed to isolate and characterize bacterial species inhabiting the pilosebaceous unit in patients with severe acne, as well as to evaluate the biofilm-forming capacity of the isolated strains. Clinical samples were cultured under anaerobic conditions, and bacterial identification was performed using 16S rRNA gene sequencing. A total of 24 bacterial isolates were obtained, with the genus Cutibacterium predominating (70.8%), including C. acnes (50%), C. avidum (12.5%), and C. granulosum (8.3%). Additionally, members of the family Enterobacteriaceae (12.5%) and other species such as Bacillus spp., Lactiplantibacillus plantarum, and Levilactobacillus brevis were detected. All C. acnes isolates exhibited biofilm-forming ability, with strain Sn9-2 demonstrating the strongest capacity. These findings highlight the predominance of Cutibacterium, particularly biofilm-forming strains, in severe acne, and underscore the potential role of biofilms in disease persistence and reduced treatment responsiveness.

https://doi.org/10.26459/hueunijns.v135i1S-1.8060
PDF (Vietnamese)

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