Effects of fabrication conditions on formation of chitosan hollow beads
Vol. 129 No. 1A (2020), Hue University Journal of Science: Natural Science
Vol. 129 No. 1A (2020)

Effects of fabrication conditions on formation of chitosan hollow beads

Hue University Journal of Science: Natural Science
https://doi.org/10.26459/hueuni-jns.v129i1A.5447
Published 2020-03-20
Pham Thi Phuong Thuy
Faculty of Biotechnology, Ho Chi Minh City University of Food Industry, 140 Le Trong Tan St., Tay Thanh Ward, Tan Phu Dist., Ho Chi Minh City, Vietnam
Le Thai Hoang
Department of Environmental Engineering, International University, Vietnam National University Ho Chi Minh City, Quarter 6, Linh Trung Ward, Thu Duc Dist., Ho Chi Minh City, Vietnam
Truong Thi Nhung
Faculty of Biotechnology, Ho Chi Minh City University of Food Industry, 140 Le Trong Tan St., Tay Thanh Ward, Tan Phu Dist., Ho Chi Minh City, Vietnam
Nguyen Thi Cam Tuyen
Department of Environmental Engineering, International University, Vietnam National University Ho Chi Minh City, Quarter 6, Linh Trung Ward, Thu Duc Dist., Ho Chi Minh City, Vietnam
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Keywords

chitosan
hollow bead
sodium tripolyphosphate chitosan
hạt rỗng
sodium tripolyphosphate

How to Cite

1.
Phương Thùy PT, Hoàng LT, Nhung TT, Cẩm Tuyên NT. Effects of fabrication conditions on formation of chitosan hollow beads. hueuni-jns [Internet]. 2020Mar.20 [cited 2024Nov.13];129(1A):87-93. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/5447
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Abstract

Chitosan has been widely used in biomedical fields due to its high biocompatibility. Especially, chitosan beads with hollow interior are gaining attention because they can absorb more drugs and release them in a sustained manner. Previous studies showed that the formation of chitosan hollow beads required organic solvents and toxic crosslinking reagents, which might limit their application in biological systems. Therefore, this study aims to fabricate chitosan beads with a core/shell structure by using simple ionic gelation in mild conditions. Chitosan synthesized from chitin was used in bead formation with sodium tripolyphosphate (STPP) as a crosslinking agent. Beads with the largest core diameter are obtained from a 2% (w/v) 205.6 kDa chitosan solution in 1% acetic acid at pH = 9 of the STPP solution.

https://doi.org/10.26459/hueuni-jns.v129i1A.5447
PDF (Vietnamese)

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