In vitro antioxidant activity and bioactive compounds from Calocybe indica


Nấm Trắng Sữa Calocybe indica
antioxidant activity
total phenolics
total flavonoid

How to Cite

Nguyen QM, Le LS, Nguyen MN, Nguyen CC, Ho XAV, Nguyen VP, Tran TM, Le TT, Tran TVT, Hieu LT. In vitro antioxidant activity and bioactive compounds from Calocybe indica. hueuni-jns [Internet]. 2021Dec.31 [cited 2023Nov.29];130(1D):15-22. Available from:


Nowadays, the use of mushrooms in medicine is ubiquitous and has achieved particular success. The antioxidants in mushrooms can deactivate free radicals. This study assesses the antioxidant potential of mushroom Calocybe indica with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging methods and the total antioxidant capacity. The mushroom’s ethanol extract exhibits acceptable activity with a low IC50 value (240.11 μg/mL), approximately 2.9 times lower than that of the mushroom Ophiocordyceps sobolifera extract. The ABTS scavenging rate of the extract is around 60% at 500 µg/mL, and the total antioxidant capacity is equivalent to 64.94 ± 1.03 mg of GA/g or 77.42 ± 0.42 μmol of AS/g.  The total phenolics, flavonoids, polysaccharides, and triterpenoids are equivalent to 29.33 ± 0.16 mg of GAE/g, 17.84 ± 0.11 mg of QUE/g (5.04 ± 0.04%), and 4.96 ± 0.04 mg of oleanolic acid/g, respectively. Specifically, the total triterpenoid content has been reported for the first time. The mushroom can have potential biomedical applications.


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