Isolation and cytotoxic activity testing of compounds from Grewia bulot
PDF (Vietnamese)

Keywords

Bù lốt
β-amyrin
quercetin
β-sitosterol
gây độc tế bào ung thư Grewia bulot
β-amyrin
quercetin
β-sitosterol
cytotoxic activity

How to Cite

1.
Tý PV, Thảo CTT, Nhàn Đặng TT, Thắng LQ, Bảo NC. Isolation and cytotoxic activity testing of compounds from Grewia bulot. hueuni-jns [Internet]. 2024Feb.25 [cited 2024May13];132(1C):15-22. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7213

Abstract

Three compounds, including β-amyrin (1), quercetin (2) and β-sitosterol (3), were isolated from the leaves of Grewia bulot. Their structures were elucidated by using infrared spectroscopy (IR) and nuclear magnetic resonance (NMR) spectroscopy and by comparing them with spectroscopic data in the literature. The cytotoxic testing results of the isolated compounds against four tested cancer cell lines (MCF-7, Hep-G2, SK-LU-1, and KB) showed that β-amyrin had weak activity on three cell lines MCF-7, Hep-G2, and SK-LU-1 with IC50 values ranging from 72.3 to 96.15 µg·mL–1. This is the first time these compounds were isolated from Grewia bulot and evaluated for their cytotoxic activity.

https://doi.org/10.26459/hueunijns.v132i1C.7213
PDF (Vietnamese)

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