Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý
Vol. 133 No. 1A (2024), Original Article
Vol. 133 No. 1A (2024)

Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý

Original Article
https://doi.org/10.26459/hueunijns.v133i1A.7264
Published 2024-03-29
Hoang Thi Nhu Hanh
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
Nguyen Thi Ngoc Kieu
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
Ho Thi Hoai Nhi
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
Ho Viet Duc*
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
PDF (Vietnamese)

How to Cite

1.
Hoàng Thị Như H, Nguyễn Thị Ngọc K, Hồ Thị Hoài N, Hồ Đức V. Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý. hueuni-jns [Internet]. 2024Mar.29 [cited 2024Apr.29];133(1A):15-22. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7264
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Abstract

Five compounds included two dihydrochalcones, 2’,6’-dihydroxy-4’-methoxydihydrochalcone (1), dihydroflavokawin B (2), one flavanone, pinocembrin (3) and two diarylheptanoids, dihydroyashabushiketol (4), 5-methoxy-1,7-diphenyl-3-heptanone (5) were isolated for the first time from the whole plants of Conamomum rubidum. The structure of isolates were determined by a combination of spectroscopic analyses as well as by comparison with the reported spectroscopic data. Biological evaluations revealed that compounds 2, 4, and 5 inhibited NO production in RAW 264.7 cells with IC50 values ranging from 58.16 ± 3.02 to 81.95 ± 2.87 µM. Compound 1 exhibited moderate cytotoxicity against the SK-LU-1 cells with IC50 value of 58.45 ± 2.26 µM.

https://doi.org/10.26459/hueunijns.v133i1A.7264
PDF (Vietnamese)

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