Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý
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1.
Hoàng Thị Như H, Nguyễn Thị Ngọc K, Hồ Thị Hoài N, Hồ Đức V. Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý. hueuni-jns [Internet]. 2024Mar.29 [cited 2024May18];133(1A):15-22. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7264

Abstract

Five compounds included two dihydrochalcones, 2’,6’-dihydroxy-4’-methoxydihydrochalcone (1), dihydroflavokawin B (2), one flavanone, pinocembrin (3) and two diarylheptanoids, dihydroyashabushiketol (4), 5-methoxy-1,7-diphenyl-3-heptanone (5) were isolated for the first time from the whole plants of Conamomum rubidum. The structure of isolates were determined by a combination of spectroscopic analyses as well as by comparison with the reported spectroscopic data. Biological evaluations revealed that compounds 2, 4, and 5 inhibited NO production in RAW 264.7 cells with IC50 values ranging from 58.16 ± 3.02 to 81.95 ± 2.87 µM. Compound 1 exhibited moderate cytotoxicity against the SK-LU-1 cells with IC50 value of 58.45 ± 2.26 µM.

https://doi.org/10.26459/hueunijns.v133i1A.7264
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