Iridoid glycosides from Gomphandra tonkinensis Gagnep.
Vol. 134 No. 1C (2025), Original Article
Vol. 134 No. 1C (2025)

Iridoid glycosides from Gomphandra tonkinensis Gagnep.

Original Article
https://doi.org/10.26459/hueunijns.v134i1C.7758
Published 2025-06-17
Tran Phan Thi Diem
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City
Ha Tran Phuong
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City
Tam Vu Thi Thanh
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Hue, Thua Thien Hue, Vietnam
Dat Ton That Huu
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Hue, Thua Thien Hue, Vietnam
Hieu Le Trung
University of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam
Le Canh Viet Cuong*
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Hue, Thua Thien Hue, Vietnam
PDF (Vietnamese)

How to Cite

1.
Phan Thị Diễm T, Trần Phương H, Vũ Thị Thanh T, Tôn Thất Hữu Đạt, Lê Trung H, Cường LCV. Iridoid glycosides from Gomphandra tonkinensis Gagnep. hueuni-jns [Internet]. 2025Jun.17 [cited 2025Oct.10];134(1C):125-33. Available from: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7758
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX
Crossref
Scopus
Google Scholar
Europe PMC

Abstract

Four iridoid glycosides, namely sweroside (1), loganin (2), triplostoside A (3), and gomphandranoside C (4), were isolated from the roots of Gomphandra tonkinensis Gagnep. collected in Thua Thien Hue. The chemical structures of isolated compounds were determined based on 1D-NMR and 2D-NMR spectral data and compared with previously published information. Compound 1 exhibits the ability to inhibit diabetes-related enzymes (α-amylase and α-glucosidase) with IC50 values ​​of 331.1 ± 8.6 µg/mL and 344.2 ± 6.0 µg/mL, respectively. Compound 2 has α-glucosidase inhibitory activity with an IC50 value of 270.9 ± 9.7 µg/mL. Triplostoside A (3) is isolated from the genus Gomphandra for the first time.

https://doi.org/10.26459/hueunijns.v134i1C.7758
PDF (Vietnamese)

References

  1. Chi VV. Từ điển cây thuốc Việt Nam. Hà Nội: Nhà xuất bản Y học; 2012.
  2. Viện Dược liệu - Bộ Y tế. Danh lục cây thuốc Việt Nam. Hà Nội: Nhà xuất bản Khoa học và Kỹ thuật; 2016.
  3. Tran Huynh Q-D, Phan T-TT, Liu T-W, Nguyen T-V, Duong T-LT, Hsu S-J, et al. Anti-inflammatory and Hepatoprotective Iridoid Glycosides from the Roots of Gomphandra mollis. Journal of Natural Products. 2025;88(2):577-92.
  4. Nguyen TK, Thuy Thi Tran L, Ho Viet D, Thai PH, Ha TP, Ty PV, et al. Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies. Heliyon. 2023;9(8):e19148.
  5. Dat TTH, Oanh PTT, Cuong LCV, Anh LT, Minh LTH, Ha H, et al. Pharmacological properties, volatile organic compounds, and genome sequences of bacterial endophytes from the mangrove plant Rhizophora apiculata Blume. Antibiotics (Basel, Switzerland). 2021;10(12):1491.
  6. Ma W-G, Fuzzati N, Wolfender J-L, Hostettmann K, Yang C-R. Rhodenthoside A, a new type of acylated secoiridoid glycoside from Gentiana rhodentha. Helvetica Chimica Acta. 1994;77(6):1660-71.
  7. Garcia J, Chulia AJ. Loganin and new iridoid glucosides in Gentiana pedicellata. Planta medica. 1986;52(04):327-9.
  8. Wei-Guang M, De-Zu W, Yu-Lin Z, Chong-Ren Y. Iridoidal glycosides from Triplostegia grandiflora. Plant Diversity. 1992;14(1):92-6.
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Copyright (c) 2025 Array