SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG
Tập 126 Số 1B (2017), Nghiên cứu
Tập 126 Số 1B (2017)

SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG

Nghiên cứu
https://doi.org/10.26459/hueuni-jns.v126i1B.4139
Đã xuất bản 2017-07-15
Duong Quoc Hoan
Department of Chemistry, Hanoi National University of Education, A4, 136 Xuan Thuy, Cau Giay, Ha Noi, Viet Nam

Tóm tắt

The acetohydrazides A5 containing an isoxazole ring and B5 containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones B6 and B7 were driven from acetohydrazide B4 by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones  B7 showing moderate reactivity against KB cancer cell line at IC50 = 57 mg/L.
https://doi.org/10.26459/hueuni-jns.v126i1B.4139
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